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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Patchouli alcohol, Cisplatin
Phytochemical Name Patchouli alcohol (PubChem CID: 10955174 )
Anticancer drug Name Cisplatin (PubChem CID: 5702198 )
Structure of
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02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 253
Ref_1
Pair Name Patchouli alcohol, Cisplatin
Disease Info [ICD-11: 2C30] Melanoma Investigative
Biological Phenomena Induction-->Blockade of cell cycle in G0/G1 phase
Gene Regulation Up-regulation Expression CDH1 hsa999
Down-regulation Phosphorylation SMAD2 hsa4087
Down-regulation Expression VIM hsa7431
Down-regulation Expression MMP2 hsa4313
Down-regulation Expression MMP9 hsa4318
In Vitro Model B16-F10 Mouse melanoma Mus musculus (Mouse) CVCL_0159
In Vivo Model B16F10 cells (1×10⁶ cells in 100 μL PBS) were subcutaneously injected into the right hind flank of the mice.
Result The effects of patchouli alcohol and combination with cisplatin on proliferation, apoptosis and migration in B16F10 melanoma cells
03. Reference
No. Title Href
1 The effects of patchouli alcohol and combination with cisplatin on proliferation, apoptosis and migration in B16F10 melanoma cells. J Cell Mol Med. 2023 May;27(10):1423-1435. doi: 10.1111/jcmm.17745. Click
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